The Role of Direct-acting Antivirals in the Treatment of Children with Chronic Hepatitis C.

ABSTRACT: In the United States, chronic infection with the hepatitis C virus (HCV) affects an estimated 0.1-2% of the pediatric population, who are consequently at risk for major complications, including cirrhosis, hepatocellular carcinoma, and death. The current standard of treatment for chronic hepatitis C (CHC) in children is pegylated-interferon-alpha (PEG-IFN) in combination with ribavirin. PEG-IFN/ribavirin therapy is approved for children ages 3 and older; however, it is often held from use until adulthood because of its extensive list of potential side effects and high likelihood of causing adverse symptoms. While CHC is usually indolent in children and adolescents, immediately treating and curbing the spread of HCV before adulthood is important, as there can be transmission to other individ

SUBMITTER: Yang CHT 

PROVIDER: S-EPMC5411358 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature