Anti-Restriction Protein, KlcA_HS, Promotes Dissemination of Carbapenem Resistance.

ABSTRACT: Carbapenemase-producing Klebsiella pneumoniae (KPC) has emerged and spread throughout the world. A retrospective analysis was performed on carbapenem-resistant K. pneumoniae isolated at our teaching hospital during the period 2009-2010, when the initial outbreak occurred. To determine the mechanism(s) that underlies the increased infectivity exhibited by KPC, Multilocus Sequence Typing (MLST) was conducted. A series of plasmids was also extracted, sequenced and analyzed. Concurrently, the complete sequences of bla_KPC-2-harboring plasmids deposited in GenBank were summarized and aligned. The bla_KPC-2 and KlcA_HS genes in the carbapenem-resistant K. pneumoniae isolates were examined. E. coli strains, carr

SUBMITTER: Liang W 

PROVIDER: S-EPMC5411435 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature