Early extracellular matrix changes are associated with later development of bronchiolitis obliterans syndrome after lung transplantation.

ABSTRACT:

Background

Chronic lung allograft dysfunction in the form of bronchiolitis obliterans syndrome (BOS) is the main cause of death beyond 1-year post-lung transplantation. The disease-initiating triggers as well as the molecular changes leading to fibrotic alterations in the transplanted lung are largely unknown. The aim of this study was to identify potential early changes in the extracellular matrix (ECM) in different compartments of the transplanted lung prior to the development of BOS.

Methods

Transbronchial biopsies from a cohort of 58 lung transplantation patients at the Copenhagen University hospital between 2005 and 2006, with or without development of BOS in a 5-year follow-up, were obtained 3 and 12 months after transplantation. Biopsies were assessed for total collag

SUBMITTER: Muller C 

PROVIDER: S-EPMC5411729 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature