Prevalence of Neurotropic Viruses in Malignant Glioma and Their Onco-Modulatory Potential.

ABSTRACT:

Background

the association between infectious agents and tumour aetiology is relevant in about 20% of cases.

Patients and methods

We tested high-grade glioma tissues from 45 patients for the presence of viral nucleic acids of six herpes viruses, human adenoviruses (A-G), and two neurotropic human viruses (enteroviruses, tick-borne encephalitis virus). Real-time polymerase chain reaction was used with immunolabelling.

Results

Three species of herpes viruses were detected: HSV-2, Epstein-Barr virus (EBV), HHV-6, and one human enterovirus. Plasma of these patients was not infected with viruses. In sera of patients, low HSV-1 and HSV-2 immunoreactivity were found in five cases, although these were not detected in their tumour tissue.

Conclusion

Certain common virus

SUBMITTER: Strojnik T 

PROVIDER: S-EPMC5411749 | biostudies-literature | 2017 Mar-Apr

REPOSITORIES: biostudies-literature