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Prevalence of Neurotropic Viruses in Malignant Glioma and Their Onco-Modulatory Potential.
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ABSTRACT: Background
the association between infectious agents and tumour aetiology is relevant in about 20% of cases.Patients and methods
We tested high-grade glioma tissues from 45 patients for the presence of viral nucleic acids of six herpes viruses, human adenoviruses (A-G), and two neurotropic human viruses (enteroviruses, tick-borne encephalitis virus). Real-time polymerase chain reaction was used with immunolabelling.Results
Three species of herpes viruses were detected: HSV-2, Epstein-Barr virus (EBV), HHV-6, and one human enterovirus. Plasma of these patients was not infected with viruses. In sera of patients, low HSV-1 and HSV-2 immunoreactivity were found in five cases, although these were not detected in their tumour tissue.Conclusion
Certain common viruses (HSV-1, HSV-2, EBV, human cytomegalovirus) are chronically present in the sera of patients with glioblastoma, but not necessarily in their tissues. Possibly both are associated with glioma progression, as we only found viruses in glioblastoma multiforme, but not in lower stages of glioma. Low titres of viruses in the blood indicate chronic viral virulence.
SUBMITTER: Strojnik T
PROVIDER: S-EPMC5411749 | biostudies-literature | 2017 Mar-Apr
REPOSITORIES: biostudies-literature
Publications
Prevalence of Neurotropic Viruses in Malignant Glioma and Their Onco-Modulatory Potential.
In vivo (Athens, Greece) 20170301 2
<h4>Background</h4>the association between infectious agents and tumour aetiology is relevant in about 20% of cases.<h4>Patients and methods</h4>We tested high-grade glioma tissues from 45 patients for the presence of viral nucleic acids of six herpes viruses, human adenoviruses (A-G), and two neurotropic human viruses (enteroviruses, tick-borne encephalitis virus). Real-time polymerase chain reaction was used with immunolabelling.<h4>Results</h4>Three species of herpes viruses were detected: HS ...[more]