ABySS 2.0: resource-efficient assembly of large genomes using a Bloom filter.

ABSTRACT: The assembly of DNA sequences de novo is fundamental to genomics research. It is the first of many steps toward elucidating and characterizing whole genomes. Downstream applications, including analysis of genomic variation between species, between or within individuals critically depend on robustly assembled sequences. In the span of a single decade, the sequence throughput of leading DNA sequencing instruments has increased drastically, and coupled with established and planned large-scale, personalized medicine initiatives to sequence genomes in the thousands and even millions, the development of efficient, scalable and accurate bioinformatics tools for producing high-quality reference draft genomes is timely. With ABySS 1.0, we originally showed that assembling the human genome using sho

SUBMITTER: Jackman SD 

PROVIDER: S-EPMC5411771 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature