Growth and stress response mechanisms underlying post-feeding regenerative organ growth in the Burmese python.

ABSTRACT:

Background

Previous studies examining post-feeding organ regeneration in the Burmese python (Python molurus bivittatus) have identified thousands of genes that are significantly differentially regulated during this process. However, substantial gaps remain in our understanding of coherent mechanisms and specific growth pathways that underlie these rapid and extensive shifts in organ form and function. Here we addressed these gaps by comparing gene expression in the Burmese python heart, liver, kidney, and small intestine across pre- and post-feeding time points (fasted, one day post-feeding, and four days post-feeding), and by conducting detailed analyses of molecular pathways and predictions of upstream regulatory molecules across these organ systems.

Results

Identified enr

SUBMITTER: Andrew AL 

PROVIDER: S-EPMC5412052 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature