Breast Cancer Risk and Progressive Histology in Serial Benign Biopsies.

ABSTRACT:

Background

More than 1 million women per year in the United States with benign breast biopsies are known to be at elevated risk for breast cancer (BC), with risk stratified on histologic categories of epithelial proliferation. Here we assessed women who had serial benign biopsies over time and how changes in the histologic classification affected BC risk.

Methods

In the Mayo Clinic Benign Breast Disease Cohort of 13 466 women, 1414 women had multiple metachronous benign biopsies (10.5%). Both initial and subsequent biopsies were assessed histologically. BC risk for clinical and prognostic factors was assessed using subdistribution models to account for competing risks, and logistic regression/Wilcoxon/chi-square tests to assess covariates. All statistical tests were two-side

SUBMITTER: Visscher DW 

PROVIDER: S-EPMC5412118 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature