A mild catalytic system for radical conjugate addition of nitrogen heterocycles.

ABSTRACT: The direct addition of pyridine and diazine units to electron-poor alkenes has been achieved via a redox radical mechanism that is enabled by limiting the effective concentration of the hydrogen-atom source. The described method is tolerant of acidic functional groups and is generally applicable to the union of a wide range of Michael acceptors and 6-membered heterocyclic halides.

SUBMITTER: Aycock RA 

PROVIDER: S-EPMC5412691 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature