MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?

ABSTRACT:

Background

Neurodegenerative and cognitive disorders are multifactorial diseases (i.e., involving neurodevelopmental, genetic, age or environmental factors) characterized by an abnormal development that affects neuronal function and integrity. Recently, an increasing number of studies revealed that the dysregulation of microRNAs (miRNAs) may be involved in the etiology of cognitive disorders as Alzheimer, Parkinson, and Huntington's diseases, Schizophrenia and Autism spectrum disorders.

Methods

From an extensive search in bibliographic databases of peer-reviewed research literature, we identified relevant published studies related to specific key words such as memory, cognition, neurodegenerative disorders, neurogenesis and miRNA. We then analysed, evaluated and summerized s

SUBMITTER: Nadim WD 

PROVIDER: S-EPMC5412695 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature