Randomized trial of inhaled nitric oxide to treat acute pulmonary embolism: The iNOPE trial.

ABSTRACT:

Background

The study hypothesis is that administration of inhaled nitric oxide (NO) plus oxygen to subjects with submassive pulmonary embolism (PE) will improve right ventricular (RV) systolic function and reduce RV strain and necrosis, while improving patient dyspnea, more than treatment with oxygen alone.

Methods

This article describes the rationale and protocol for a registered (NCT01939301), nearly completed phase II, 3-center, randomized, double-blind, controlled trial. Eligible patients have pulmonary imaging-proven acute PE. Subjects must be normotensive, and have RV dysfunction on echocardiography or elevated troponin or brain natriuretic peptide and no fibrinolytics. Subjects receive NO plus oxygen or placebo for 24 hours (±3 hours) with blood sampling before and af

SUBMITTER: Kline JA 

PROVIDER: S-EPMC5412723 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature