Niacin ameliorates ulcerative colitis via prostaglandin D₂-mediated D prostanoid receptor 1 activation.

ABSTRACT: Niacin, as an antidyslipidemic drug, elicits a strong flushing response by release of prostaglandin (PG) D₂ However, whether niacin is beneficial for inflammatory bowel disease (IBD) remains unclear. Here, we observed niacin administration-enhanced PGD₂ production in colon tissues in dextran sulfate sodium (DSS)-challenged mice, and protected mice against DSS or 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in D prostanoid receptor 1 (DP1)-dependent manner. Specific ablation of DP1 receptor in vascular endothelial cells, colonic epithelium, and myeloid cells augmented DSS/TNBS-induced colitis in mice through increasing vascular permeability, promoting apoptosis of epithelial cells, and stimulating pro-inflammatory cytokine secretion of macrophages, respec

SUBMITTER: Li J 

PROVIDER: S-EPMC5412792 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature