Sex-specific, reciprocal regulation of ERα and miR-22 controls muscle lipid metabolism in male mice.

ABSTRACT: Control of energy homeostasis and metabolism is achieved by integrating numerous pathways, and miRNAs are involved in this process by regulating expression of multiple target genes. However, relatively little is known about the posttranscriptional processing of miRNAs and a potential role for the precursors they derive from. Here, we demonstrate that mature miRNA-22 is more abundant in muscle from male mice relative to females and that this enables sex-specific regulation of muscular lipid metabolism and body weight by repressing estrogen receptor alpha (ERα) expression. We found that the ERα adjusts its own activity by preventing processing of miR-22 via direct binding to a conserved ERα-binding element within the primary miR-22 precursor. Mutation of the ERα binding site within the pri-m

SUBMITTER: Schweisgut J 

PROVIDER: S-EPMC5412813 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature