18F-FDG uptake in the colon is modulated by metformin but not associated with core body temperature and energy expenditure.

ABSTRACT:

Purpose

Physiological colonic 18F-fluorodeoxyglucose (18F-FDG) uptake is a frequent finding on 18F-FDG positron emission tomography computed tomography (PET-CT). Interestingly, metformin, a glucose lowering drug associated with moderate weight loss, is also associated with an increased colonic 18F-FDG uptake. Consequently, increased colonic glucose use might partly explain the weight losing effect of metformin when this results in an increased energy expenditure and/or core body temperature. Therefore, we aimed to determine whether metformin modifies the metabolic activity of the colon by increasing glucose uptake.

Methods

In this open label, non-randomized, prospective mechanistic study, we included eight lean and eight overweight males. We measured colonic 18F-FDG uptake o

SUBMITTER: Bahler L 

PROVIDER: S-EPMC5413044 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature