Screening candidate microRNAs (miRNAs) in different lambskin hair follicles in Hu sheep.

ABSTRACT: Hu sheep lambskin is a unique white lambskin from China that exhibits three types of flower patterns, including small waves, medium waves, and large waves, with small waves considered the best quality. However, our understanding of the molecular mechanism underlying flower pattern formation in Hu sheep lambskin is limited. The aim of the present study was to further explore the relevance between candidate microRNAs (miRNAs) and developmental characteristics of hair follicles and screen miRNAs for later functional validation. Herein, we employed Illumina Hiseq 2500 to identify differentially expressed miRNAs in hair follicles of different flower patterns with small, medium, and large waves to construct a comprehensive sequence database on the mechanism of hair follicle development. Paraffin

SUBMITTER: Gao W 

PROVIDER: S-EPMC5413071 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature