Effects of Oxandrolone on Cardiometabolic Health in Boys With Klinefelter Syndrome: A Randomized Controlled Trial.

ABSTRACT:

Context

Klinefelter syndrome (KS) is a common condition in males, resulting in androgen deficiency and cardiometabolic diseases. These interrelated conditions may be present in prepubertal boys with KS.

Objective

To determine whether supplemental low-dose androgen has a beneficial effect on body composition in prepubertal boys with KS.

Design, setting, and participants

We conducted a secondary analysis of a randomized, double-blind, placebo-controlled clinical trial in 93 boys with KS aged 4 to 12 years.

Interventions

Oral oxandrolone (Ox) 0.06 mg/kg/d or placebo for 2 years.

Outcome measures

The primary outcome was percent body fat standard deviation score (%BF SDS) at 2 years. Secondary outcomes included additional measures of cardiometabolic health an

SUBMITTER: Davis SM 

PROVIDER: S-EPMC5413098 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature