Genetic Variations of Circulating Adiponectin Levels Modulate Changes in Appetite in Response to Weight-Loss Diets.

ABSTRACT:

Context

Adiponectin plays key roles in regulating appetite and food intake.

Objective

To investigate interactions between the genetic risk score (GRS) for adiponectin levels and weight-loss diets varying in macronutrient intake on long-term changes in appetite and adiponectin levels.

Design, setting, and participants

A GRS was calculated based on 5 adiponectin-associated variants in 692 overweight adults from the 2-year Preventing Overweight Using Novel Dietary Strategies trial.

Main outcome measures

Repeated measurements of plasma adiponectin levels and appetite-related traits, including cravings, fullness, prospective consumption, and hunger.

Results

Dietary fat showed nominally significant interactions with the adiponectin GRS on changes in appetite s

SUBMITTER: Ma W 

PROVIDER: S-EPMC5413100 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature