The Consistency in Macronutrient Oxidation and the Role for Epinephrine in the Response to Fasting and Overfeeding.

ABSTRACT:

Context

In humans, dietary vs intraindividual determinants of macronutrient oxidation preference and the role of the sympathetic nervous system (SNS) during short-term overfeeding and fasting are unclear.

Objective

To understand the influence on metabolic changes of diet and SNS during 24 hours of overfeeding.

Design, setting, participants, and interventions

While residing on a clinical research unit, 64 participants with normal glucose regulation were assessed during energy balance, fasting, and four 24-hour overfeeding diets, given in random order. The overfeeding diets contained 200% of energy requirements and varied macronutrient proportions: (1) standard (50% carbohydrate, 20% protein, and 30% fat); (2) 75% carbohydrate; (3) 60% fat; and (4) 3% protein.

Main o

SUBMITTER: Vinales KL 

PROVIDER: S-EPMC5413106 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature