Relationship Between Gastric Emptying and Diurnal Glycemic Control in Type 1 Diabetes Mellitus: A Randomized Trial.

ABSTRACT:

Context

In type 1 diabetes (T1D), delayed gastric emptying (GE) may predispose to a mismatch between insulin delivery and glucose absorption. Previous studies evaluated, only partly, the relationship between delayed GE and postprandial, but not diurnal, glycemia.

Objective

To assess the relationship between GE disturbances and glycemic control in T1D and the effects of accelerating GE on glycemic control.

Design, setting, and participants

This was a randomized placebo-controlled trial in 30 patients with T1D on an insulin pump at an academic medical center.

Intervention(s)

GE was evaluated with a [13C]-Spirulina breath test at baseline (GEbaseline), during intravenous saline or erythromycin (2 or 3 mg/kg; GEiv), and after 7 days of oral erythromycin or placebo

SUBMITTER: Parthasarathy G 

PROVIDER: S-EPMC5413165 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature