Distinct Actions of Voltage-Activated Ca²⁺ Channel Block on Spontaneous Release at Excitatory and Inhibitory Central Synapses.

ABSTRACT: At chemical synapses, voltage-activated calcium channels (VACCs) mediate Ca²⁺ influx to trigger action potential-evoked neurotransmitter release. However, the mechanisms by which Ca²⁺ regulates spontaneous transmission have not been fully determined. We have shown that VACCs are a major trigger of spontaneous release at neocortical inhibitory synapses but not at excitatory synapses, suggesting fundamental differences in spontaneous neurotransmission at GABAergic and glutamatergic synapses. Recently, VACC blockers were reported to reduce spontaneous release of glutamate and it was proposed that there was conservation of underlying mechanisms of neurotransmission at excitatory and inhibitory synapses. Furthermore, it was hypothesized that the different effects on excita

SUBMITTER: Tsintsadze T 

PROVIDER: S-EPMC5413177 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature