BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection.

ABSTRACT: Inappropriate IL-17 responses are implicated in chronic tissue inflammation. IL-23 contributes to Trypanosoma cruzi-specific IL-17 production, but the molecular mechanisms underlying regulation of the IL-23-IL-17 axis during T. cruzi infection are poorly understood. Here, we demonstrate a novel function of BATF2 as a negative regulator of Il23a in innate immune cells. IL-17, but not IFN-γ, was more highly produced by CD4⁺ T cells from spleens and livers of T. cruzi-infected Batf2^-/- mice than by those of wild-type mice. In this context, Batf2^-/- mice showed severe multiorgan pathology despite reduced parasite burden. T. cruzi-induced IL-23 production was increased in Batf2^-/- innate immune c

SUBMITTER: Kitada S 

PROVIDER: S-EPMC5413328 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature