Ontology highlight
ABSTRACT:
SUBMITTER: A-Gonzalez N
PROVIDER: S-EPMC5413334 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20170421 5
Tissue-resident macrophages display varying phenotypic and functional properties that are largely specified by their local environment. One of these functions, phagocytosis, mediates the natural disposal of billions of cells, but its mechanisms and consequences within living tissues are poorly defined. Using a parabiosis-based strategy, we identified and isolated macrophages from multiple tissues as they phagocytosed blood-borne cellular material. Phagocytosis was circadianally regulated and med ...[more]