BMI loci and longitudinal BMI from adolescence to young adulthood in an ethnically diverse cohort.

ABSTRACT:

Objective

The association of obesity susceptibility variants with change in body mass index (BMI) across the life course is not well understood.

Subjects

In ancestry-stratified models of 5962 European American (EA), 2080 African American (AA) and 1582 Hispanic American (HA) individuals from the National Longitudinal Study of Adolescent to Adult Health (Add Health), we examined associations between 34 obesity single-nucleotide polymorphisms (SNPs) with per year change in BMI, measured by the slope from a growth-curve analysis of two or more BMI measurements between adolescence and young adulthood. For SNPs nominally associated with BMI change (P<0.05), we interrogated age differences within data collection Wave and time differences between age categories that overlapped betwe

SUBMITTER: Graff M 

PROVIDER: S-EPMC5413409 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature