Endometrial Cancer Risk Factors, Hormone Receptors, and Mortality Prediction.

ABSTRACT: Background: Endometrial tumors arise from a hormonally responsive tissue. Defining subtypes by hormone receptor expression might better inform etiology and prediction of patient outcomes. We evaluated the potential role of tumor estrogen receptor (ER) and progesterone receptor (PR) expression to define endometrial cancer subtypes.Methods: We measured semi-continuous ER and PR protein expression in tissue specimens from 360 endometrial primary tumors from the Nurses' Health Study. To explore the impact of different definitions of marker positivity, we dichotomized ER and PR expression at different cut points in increments of 5% positive cells. Logistic regression was used to estimate associations between endometrial cancer risk factors, such as body mass index, with dichotomou

SUBMITTER: Busch EL 

PROVIDER: S-EPMC5413416 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature