Genetic Manipulation of Helicobacter pylori Virulence Function by Host Carcinogenic Phenotypes.

ABSTRACT: Helicobacter pylori is the strongest risk factor for gastric adenocarcinoma, yet only a minority of infected persons ever develop this malignancy. One cancer-linked locus is the cag type 4 secretion system (cagT4SS), which translocates an oncoprotein into host cells. A structural component of the cagT4SS is CagY, which becomes rapidly altered during in vivo adaptation in mice and rhesus monkeys, rendering the cagT4SS nonfunctional; however, these models rarely develop gastric cancer. We previously demonstrated that the H. pylori cag⁺ strain 7.13 rapidly induces gastric cancer in Mongolian gerbils. We now use this model, in conjunction with samples from patients with premalignant lesions, to define the effects of a carcinogenic hos

SUBMITTER: Suarez G 

PROVIDER: S-EPMC5413443 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature