Functional compared to anatomical imaging in the initial evaluation of patients with suspected coronary artery disease: An international, multi-center, randomized controlled trial (IAEA-SPECT/CTA study).

ABSTRACT:

Objective

To test the hypothesis that, in the initial evaluation of patients with suspected coronary artery disease (CAD), stress myocardial perfusion imaging (MPI) would result in less downstream testing than coronary computed tomographic angiography (CCTA).

Methods

In this international, randomized trial, mildly symptomatic patients with an intermediate likelihood of having CAD, and asymptomatic patients at intermediate risk of cardiac events, underwent either initial stress-rest MPI or CCTA. The primary outcome was downstream noninvasive or invasive testing at 6 months. Secondary outcomes included cumulative effective radiation dose (ERD) and costs at 12 months.

Results

We recruited 303 patients (151 MPI and 152 CTA) from 6 centers in 6 countries. The initial MPI w

SUBMITTER: Karthikeyan G 

PROVIDER: S-EPMC5413523 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature