Plasma levels of danger-associated molecular patterns are associated with immune suppression in trauma patients.

ABSTRACT:

Purpose

Danger-associated molecular patterns (DAMPs) released of trauma could contribute to an immune suppressed state that renders patients vulnerable towards nosocomial infections. We investigated DAMP release in trauma patients, starting in the prehospital phase, and assessed its relationship with immune suppression and nosocomial infections.

Methods

Blood was obtained from 166 adult trauma patients at the trauma scene, emergency room (ER), and serially afterwards. Circulating levels of DAMPs and cytokines were determined. Immune suppression was investigated by determination of HLA-DRA gene expression and ex vivo lipopolysaccharide-stimulated cytokine production.

Results

Compared with healthy controls, plasma levels of nuclear DNA (nDNA) and heat shock protein-70 (

SUBMITTER: Timmermans K 

PROVIDER: S-EPMC5413532 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature