Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer's Disease.

ABSTRACT: Current hypotheses and theories regarding the pathogenesis of Alzheimer's disease (AD) heavily implicate brain insulin resistance (IR) as a key factor. Despite the many well-validated metrics for systemic IR, the absence of biomarkers for brain-specific IR represents a translational gap that has hindered its study in living humans. In our lab, we have been working to develop biomarkers that reflect the common mechanisms of brain IR and AD that may be used to follow their engagement by experimental treatments. We present two promising biomarkers for brain IR in AD: insulin cascade mediators probed in extracellular vesicles (EVs) enriched for neuronal origin, and two-dimensional magnetic resonance spectroscopy (MRS) measures of brain glucose. As further evidence for a fundamental link betwee

SUBMITTER: Mullins RJ 

PROVIDER: S-EPMC5413582 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature