From Maxwell's equations to the theory of current-source density analysis.

ABSTRACT: Despite the widespread use of current-source density (CSD) analysis of extracellular potential recordings in the brain, the physical mechanisms responsible for the generation of the signal are still debated. While the extracellular potential is thought to be exclusively generated by the transmembrane currents, recent studies suggest that extracellular diffusive, advective and displacement currents-traditionally neglected-may also contribute considerably toward extracellular potential recordings. Here, we first justify the application of the electro-quasistatic approximation of Maxwell's equations to describe the electromagnetic field of physiological origin. Subsequently, we perform spatial averaging of currents in neural tissue to arrive at the notion of the CSD and derive an equation rel

SUBMITTER: Gratiy SL 

PROVIDER: S-EPMC5413824 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature