Molecular classification of urothelial carcinoma: global mRNA classification versus tumour-cell phenotype classification.

ABSTRACT: Global mRNA expression analysis is efficient for phenotypic profiling of tumours, and has been used to define molecular subtypes for almost every major tumour type. A key limitation is that most tumours are communities of both tumour and non-tumour cells. This problem is particularly pertinent for analysis of advanced invasive tumours, which are known to induce major changes and responses in both the tumour and the surrounding tissue. To identify bladder cancer tumour-cell phenotypes and compare classification by tumour-cell phenotype with classification by global gene expression analysis, we analysed 307 advanced bladder cancers (cystectomized) both by genome gene expression analysis and by immunohistochemistry with antibodies for 28 proteins. According to systematic analysis of gene and

SUBMITTER: Sjodahl G 

PROVIDER: S-EPMC5413843 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature