Sevoflurane-induced isoelectric EEG and burst suppression: differential and antagonistic effect of added nitrous oxide.

ABSTRACT: The objective of this study was to investigate whether nitrous oxide influenced the ED50 of sevoflurane for induction of isoelectric electroencephalogram (ED50_isoelectric ) differently from its influence on the ED50 of sevoflurane for electroencephalogram burst suppression (ED50_burst ). In a prospective, randomised, double-blind, parallel group, up-down sequential allocation study, 77 ASA physical status 1 and 2 patients received sevoflurane induction and, after tracheal intubation, were randomly allocated to receive sevoflurane with either 40% oxygen in air (control group) or 60% nitrous oxide in oxygen mixture (nitrous group). The ED50_isoelectric in the two groups was determined using Dixon's up and down method, starting at 2.5% with 0.2% step size of end

SUBMITTER: Niu B 

PROVIDER: S-EPMC5413860 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature