MiR-137: an important player in neural development and neoplastic transformation.

ABSTRACT: MicroRNAs (miRNAs) represent an important class of small regulatory RNAs that control gene expression posttranscriptionally by targeting mRNAs for degradation or translation inhibition. Early studies have revealed a complex role for miRNAs in major biological processes such as development, differentiation, growth and metabolism. MiR-137 in particular, has been of great interest due to its critical role in brain function and putative involvement in the etiology of both neuropsychiatric disorders and cancer. Several lines of evidence suggest that development, differentiation and maturation of the nervous system is strongly linked to the expression of miR-137 and its regulation of a large number of downstream target genes in various pathways. Dysregulation of this molecule has also been impli

SUBMITTER: Mahmoudi E 

PROVIDER: S-EPMC5414082 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature