Post-operative atrial fibrillation examined using whole-genome RNA sequencing in human left atrial tissue.

ABSTRACT:

Background

Both ambulatory atrial fibrillation (AF) and post-operative AF (poAF) are associated with substantial morbidity and mortality. Analyzing the tissue-specific gene expression in the left atrium (LA) can identify novel genes associated with AF and further the understanding of the mechanism by which previously identified genetic variants associated with AF mediate their effects.

Methods

LA free wall samples were obtained intraoperatively immediately prior to mitral valve surgery in 62 Caucasian individuals. Gene expression was quantified on mRNA harvested from these samples using RNA sequencing. An expression quantitative trait loci (eQTL) analysis was performed, comparing gene expression between different genotypes of 1.0 million genetic markers, emphasizing genomic

SUBMITTER: Sigurdsson MI 

PROVIDER: S-EPMC5414158 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature