Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population.

ABSTRACT:

Background

The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations.

Methods

A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression. Generalized linear models were used to test for associations and gene-gene interactions affecting BMI, WC and FTO expression.

Results

FTO and ABCA1 risk alleles were not individually associated with higher BMI or WC. However, in th

SUBMITTER: Villalobos-Comparan M 

PROVIDER: S-EPMC5414298 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature