Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllers.

ABSTRACT:

Background

Ongoing intra-host HIV-1 evolution has been shown in individuals that naturally suppress the viremia to low levels (HIV controllers) by the analysis of the RNA in plasma compartment. Detection of evolution at the DNA proviral compartment in HIV controllers, however, has been more challenging and the precise correlation between the systemic viral suppression level and rate of reservoir's reseeding in those individuals is not fully understood. In this sense, we examined the proviral DNA quasispecies by single genome amplification of the env gene in a cohort of 23 HIV controllers from Brazil, divided in three groups, according to the level of systemic viral suppression: (1) elite controllers with persistent undetectable viral load (PEC, n = 6); (2) elite controllers with oc

SUBMITTER: de Azevedo SSD 

PROVIDER: S-EPMC5414336 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature