Sympathetic Innervation of Cold-Activated Brown and White Fat in Lean Young Adults.

ABSTRACT: Recent work in rodents has demonstrated that basal activity of the local sympathetic nervous system is critical for maintaining brown adipocyte phenotypes in classic brown adipose tissue (BAT) and white adipose tissue (WAT). Accordingly, we sought to assess the relationship between sympathetic innervation and cold-induced activation of BAT and WAT in lean young adults. Methods: Twenty adult lean normal subjects (10 women and 10 men; mean age ± SD, 23.3 ± 3.8 y; body mass index, 23.7 ± 2.5 kg/m²) underwent ¹¹C-meta-hydroxyephedrin (¹¹C-HED) and ¹⁵O-water PET imaging at rest and after exposure to mild cold (16°C) temperature. In addition, ¹⁸F-FDG images were obtained during the cold stress condition to assess cold-activated BAT ma

SUBMITTER: Muzik O 

PROVIDER: S-EPMC5414500 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature