Involvement of connexin43 in acetaminophen-induced liver injury.

ABSTRACT:

Background and aims

Being goalkeepers of liver homeostasis, gap junctions are also involved in hepatotoxicity. However, their role in this process is ambiguous, as gap junctions can act as both targets and effectors of liver toxicity. This particularly holds true for drug-induced liver insults. In the present study, the involvement of connexin26, connexin32 and connexin43, the building blocks of liver gap junctions, was investigated in acetaminophen-induced hepatotoxicity.

Methods

C57BL/6 mice were overdosed with 300mg/kg body weight acetaminophen followed by analysis of the expression and localization of connexins as well as monitoring of hepatic gap junction functionality. Furthermore, acetaminophen-induced liver injury was compared between mice genetically deficient in co

SUBMITTER: Maes M 

PROVIDER: S-EPMC5414847 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature