Characterization of a human anti-tumoral NK cell population expanded after BCG treatment of leukocytes.

ABSTRACT: Immunotherapy, via intra-vesical instillations of BCG, is the therapy of choice for patients with high-risk non-muscle invasive bladder cancer. The subsequent recruitment of lymphocytes and myeloid cells, as well as the release of cytokines and chemokines, is believed to induce a local immune response that eliminates these tumors, but the detailed mechanisms of action of this therapy are not well understood. Here, we have studied the phenotype and function of the responding lymphocyte populations as well as the spectrum of cytokines and chemokines produced in an in vitro model of human peripheral blood mononuclear cells (PBMCs) co-cultured with BCG. Natural killer (NK) cell activation was a prominent feature of this immune response and we have studied the expansion of this lymphocyt

SUBMITTER: Garcia-Cuesta EM 

PROVIDER: S-EPMC5414876 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature