Ontology highlight
ABSTRACT:
SUBMITTER: Labiano S
PROVIDER: S-EPMC5414881 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Labiano Sara S Meléndez-Rodríguez Florinda F Palazón Asís A Teijeira Álvaro Á Garasa Saray S Etxeberria Iñaki I Aznar M Ángela MÁ Sánchez-Paulete Alfonso R AR Azpilikueta Arantza A Bolaños Elixabet E Molina Carmen C de la Fuente Hortensia H Maiso Patricia P Sánchez-Madrid Francisco F de Landázuri Manuel Ortiz MO Aragonés Julián J Melero Ignacio I
Oncoimmunology 20170119 4
CD69 is an early activation marker on the surface of T lymphocytes undergoing activation by cognate antigen. We observed intense expression of CD69 on tumor-infiltrating T-lymphocytes that reside in the hypoxic tumor microenvironment and hypothesized that CD69 could be, at least partially, under the control of the transcriptional hypoxia response. In line with this, human and mouse CD3-stimulated lymphocytes cultured under hypoxia (1% O<sub>2</sub>) showed increased expression of CD69 at the pro ...[more]