Quantification of the efficacy of collagen cross-linking agents to induce stiffening of rat sclera.

ABSTRACT: The concept of scleral stiffening therapies has emerged as a novel theoretical approach for treating the ocular disorders glaucoma and myopia. Deformation of specific regions of the posterior eye is innately involved in the pathophysiology of these diseases, and thus targeted scleral stiffening could resist these changes and slow or prevent progression of these diseases. Here, we present the first systematic screen and direct comparison of the stiffening effect of small molecule collagen cross-linking agents in the posterior globe, namely using glyceraldehyde, genipin and methylglyoxal (also called pyruvaldehyde). To establish a dose-response relationship, we used inflation testing to simulate the effects of increasing intraocular pressure in freshly harvested rat eyes stiffened with multi

SUBMITTER: Campbell IC 

PROVIDER: S-EPMC5414911 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature