Spatial regulation of bone morphogenetic proteins (BMPs) in postnatal articular and growth plate cartilage.

ABSTRACT: Articular and growth plate cartilage both arise from condensations of mesenchymal cells, but ultimately develop important histological and functional differences. Each is composed of three layers-the superficial, mid and deep zones of articular cartilage and the resting, proliferative and hypertrophic zones of growth plate cartilage. The bone morphogenetic protein (BMP) system plays an important role in cartilage development. A gradient in expression of BMP-related genes has been observed across growth plate cartilage, likely playing a role in zonal differentiation. To investigate the presence of a similar expression gradient in articular cartilage, we used laser capture microdissection (LCM) to separate murine growth plate and articular cartilage from the proximal tibia into their six con

SUBMITTER: Garrison P 

PROVIDER: S-EPMC5414995 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature