Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.

ABSTRACT: The functionality of stem cells declines during ageing, and this decline contributes to ageing-associated impairments in tissue regeneration and function. Alterations in developmental pathways have been associated with declines in stem-cell function during ageing, but the nature of this process remains poorly understood. Hox genes are key regulators of stem cells and tissue patterning during embryogenesis with an unknown role in ageing. Here we show that the epigenetic stress response in muscle stem cells (also known as satellite cells) differs between aged and young mice. The alteration includes aberrant global and site-specific induction of active chromatin marks in activated satellite cells from aged mice, resulting in the specific induction of Hoxa9 but not other Hox genes. Hoxa9 in tu

SUBMITTER: Schworer S 

PROVIDER: S-EPMC5415306 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature