Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life.

ABSTRACT: Maturation and migration to lymph nodes (LNs) constitutes a central paradigm in conventional dendritic cell (cDC) biology but remains poorly defined in humans. Using our organ donor tissue resource, we analyzed cDC subset distribution, maturation, and migration in mucosal tissues (lungs, intestines), associated lymph nodes (LNs), and other lymphoid sites from 78 individuals ranging from less than 1 year to 93 years of age. The distribution of cDC1 (CD141^hiCD13^hi) and cDC2 (Sirp-α⁺CD1c⁺) subsets was a function of tissue site and was conserved between donors. We identified cDC2 as the major mature (HLA-DR^hi) subset in LNs with the highest frequency in lung-draining LNs. Mature cDC2 in mucosal-draining LNs expressed tissue-specific marker

SUBMITTER: Granot T 

PROVIDER: S-EPMC5415308 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature