Tumor-induced Stromal STAT1 Accelerates Breast Cancer via Deregulating Tissue Homeostasis.

ABSTRACT: The tumor microenvironment (TME), the dynamic tissue space in which the tumor exists, plays a significant role in tumor initiation, and is a key contributor in cancer progression; however, little is known about tumor-induced changes in the adjacent tissue stroma. Herein, tumor-induced changes in the TME were explored at the morphologic and molecular level to further understand cancer progression. Tumor-adjacent mammary glands (TAG) displayed altered branching morphology, expansion of myofibroblasts, and increased mammosphere formation, broadly suggesting a tumor-induced field effect. FACS analysis of TAGs demonstrated an increased number of Lin^-CD24⁺/CD49⁺ enriched mammary gland stem cells (MaSC), suggesting deregulated tissue homeostasis in TAGs. Comparati

SUBMITTER: Zellmer VR 

PROVIDER: S-EPMC5415415 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature