HPV16-E7-Specific Activated CD8 T Cells in E7 Transgenic Skin and Skin Grafts.

ABSTRACT: Human papillomavirus (HPV) 16 E7 (E7) protein expression in skin promotes epithelial hyperproliferation and transformation to malignancy. Grafts of murine skin expressing E7 protein as a transgene in keratinocytes are not rejected from immunocompetent recipients, whereas grafts expressing ovalbumin (OVA), with or without coexpression of E7 protein, are promptly rejected, demonstrating that E7-associated non-antigen-specific local immunosuppression is not a major determinant of lack of rejection of E7 transgenic skin. To determine whether failure of rejection of E7 skin grafts is due to failure to attract E7-specific effector T cells, E7- and OVA-specific effector CD8⁺ T cells, activated in vitro, were transferred to animals bearing E7 transgenic skin grafts. Three days af

SUBMITTER: Jazayeri SD 

PROVIDER: S-EPMC5415560 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature