Novel β-Lactamase bla_ARL in Staphylococcus arlettae.

ABSTRACT: Whole-genome sequencing of penicillin-resistant Staphylococcus arlettae strain SAN1670 from bovine mastitis milk revealed a novel β-lactamase operon consisting of the β-lactamase-encoding gene bla_ARL, the antirepressor-encoding gene blaR1_ARL, and the repressor-encoding gene blaI_ARL. The functionality of bla_ARL was demonstrated by gene expression in Staphylococcus aureus. The bla_ARL operon was chromosomally located in SAN1670 and present in 10 additional unrelated strains, suggesting intrinsic penicillin resistance in S. arlettae. Furthermore, a GenBank search revealed more unique potential β-lactamases in Staphylococcus species. IMPORTANCE Penicillins are an importan

SUBMITTER: Andreis SN 

PROVIDER: S-EPMC5415633 | biostudies-literature | 2017 May-Jun

REPOSITORIES: biostudies-literature