Monocytic thrombomodulin promotes cell adhesion through interacting with its ligand, Lewis^y.

ABSTRACT: The leukocyte adhesion cascade involves multiple events that efficiently localize circulating leukocytes into the injured sites to mediate inflammatory responses. From rolling to firm adhesion, the interactions between adhesion molecules have pivotal roles in increasing the avidity of leukocytes to endothelial cells. Thrombomodulin (TM), an essential anticoagulant protein in the vasculature, is also expressed on leukocytes. We previously demonstrated that Lewis^y (Le^y), a specific ligand of TM, is upregulated in inflamed endothelium and is involved in leukocyte adhesion. The current study aimed to investigate whether leukocyte-expressed TM promotes cell adhesion by interacting with Le^y. Using human monocytic THP-1 cells as an in vitro cell model, we showed t

SUBMITTER: Lin WL 

PROVIDER: S-EPMC5415637 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature