Influence of the Steric Bulk and Solvent on the Photoreactivity of Ruthenium Polypyridyl Complexes Coordinated to l-Proline.

ABSTRACT: Ruthenium polypyridyl complexes are good candidates for photoactivated chemotherapy (PACT) provided that they are stable in the dark but efficiently photosubstitute one of their ligands. Here the use of the natural amino acid l-proline as a protecting ligand for ruthenium-based PACT compounds is investigated in the series of complexes Λ-[Ru(bpy)₂(l-prol)]PF₆ ([1a]PF₆; bpy = 2,2'-bipyridine and l-prol = l-proline), Λ-[Ru(bpy)(dmbpy)(l-prol)]PF₆ ([2a]PF₆ and [2b]PF₆; dmbpy = 6,6'-dimethyl-2,2'-bipyridine), and Λ-[Ru(dmbpy)₂(l-prol)]PF₆ ([3a]PF₆). The synthesis of the tris-heteroleptic complex bearing the dissymmetric proline ligand yielded only two of the four possible regioisomers, called [2a]

SUBMITTER: Cuello-Garibo JA 

PROVIDER: S-EPMC5415878 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature