Self-Assembling Peptide Epitopes as Novel Platform for Anticancer Vaccination.

ABSTRACT: The aim of the present study was to improve the immunogenicity of peptide epitope vaccines using novel nanocarriers based on self-assembling materials. Several studies demonstrated that peptide antigens in nanoparticulate form induce stronger immune responses than their soluble forms. However, several issues such as poor loading and risk of inducing T cell anergy due to premature release of antigenic epitopes have challenged the clinical success of such systems. In the present study, we developed two vaccine delivery systems by appending a self-assembling peptide (Ac-AAVVLLLW-COOH) or a thermosensitive polymer poly(N-isopropylacrylamide (pNIPAm) to the N-terminus of different peptide antigens (OVA_250-264, HPV-E7_43-57) to generate self-assembling peptide epitopes (SAPE

SUBMITTER: Rad-Malekshahi M 

PROVIDER: S-EPMC5415879 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature