Integrated transcriptome and methylome analysis in youth at high risk for bipolar disorder: a preliminary analysis.

ABSTRACT: First-degree relatives of patients with bipolar disorder (BD), particularly their offspring, have a higher risk of developing BD and other mental illnesses than the general population. However, the biological mechanisms underlying this increased risk are still unknown, particularly because most of the studies so far have been conducted in chronically ill adults and not in unaffected youth at high risk. In this preliminary study we analyzed genome-wide expression and methylation levels in peripheral blood mononuclear cells from children and adolescents from three matched groups: BD patients, unaffected offspring of bipolar parents (high risk) and controls (low risk). By integrating gene expression and DNA methylation and comparing the lists of differentially expressed genes and differential

SUBMITTER: Fries GR 

PROVIDER: S-EPMC5416675 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature