Longitudinal relationships among activity in attention redirection neural circuitry and symptom severity in youth.

ABSTRACT:

Background

Changes in neural circuitry function may be associated with longitudinal changes in psychiatric symptom severity. Identification of these relationships may aid in elucidating the neural basis of psychiatric symptom evolution over time. We aimed to distinguish these relationships using data from the Longitudinal Assessment of Manic Symptoms (LAMS) cohort.

Methods

Forty-one youth completed two study visits (mean=21.3 months). Elastic-net regression (Multiple response Gaussian family) identified emotional regulation neural circuitry that changed in association with changes in depression, mania, anxiety, affect lability, and positive mood and energy dysregulation, accounting for clinical and demographic variables.

Results

Non-zero coefficients between change in

SUBMITTER: Bertocci MA 

PROVIDER: S-EPMC5416876 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature